How To Use

Easy As 1,2, … That’s It.

In a patient survey, 88% of women said IMVEXXY is easy to use. And 80% found it easy to insert.*

Let us show you how to use IMVEXXY in just a couple quick steps.

*A patient survey evaluated the acceptability of the product administration experience and was completed at the end of a 12-week study by women in 4-mcg, 10-mcg, and matching softgel placebo arms (N=574).


Hold the IMVEXXY capsule between your fingers with the smaller end facing up.



With the smaller end of the capsule still facing up, use your finger to place the insert about 2 inches into your vagina.

Insert IMVEXXY lying down or standing up, whichever is more comfortable for you.

And That’s It.
No Messy Applicators.




2 weeks





Continue as long as you and your healthcare provider feel you need it, consistent with your treatment goals and risks.

Save On Your Prescription.

Everyone should be able to afford treatment for their menopausal symptoms. That’s why we’ve created a savings program to help lower your prescription costs. Find out how you can get IMVEXXY for as little as $35* with our savings card.


*Savings card offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please see Program Terms, Conditions, and Eligibility Criteria. Medicare cash paying and other cash paying patients may save through vitaCare Prescription Services.


IMVEXXY (estradiol vaginal inserts) is a prescription medicine that contains an estrogen hormone in a vaginal insert. It is used after menopause to treat moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Important Risk Information


  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Report any unusual vaginal bleeding right away while you are using IMVEXXY. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone or with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogen-alone or with progestin may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone or with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • Talk to your doctor regularly about whether you still need treatment with IMVEXXY.

Do not use if you

  • have unusual vaginal bleeding.
  • currently have or have had certain cancers.
  • currently have or have had blood clots.
  • had a stroke or heart attack.
  • currently have or have had liver problems.
  • have been diagnosed with a bleeding disorder.
  • are allergic to IMVEXXY or any of its ingredients.
  • think you may be pregnant.


Tell your healthcare provider about all of your medical conditions, including if you:

  • have any unusual vaginal bleeding.
  • have asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
  • are going to have surgery or will be on bed rest. You may need to stop using IMVEXXY.
  • are breast feeding.

Tell your healthcare provider about all the medicines you take.

IMVEXXY may affect the way other medicines work, and other medicines may affect how IMVEXXY works.

When using IMVEXXY you may have

  • headache
  • breast tenderness or pain
  • nausea and vomiting

The risk information provided here is not complete. To learn more, talk about IMVEXXY with your healthcare provider or pharmacist. The FDA-approved product labeling can be found here.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch, or call 1-800-FDA-1088. You may also report side effects to TherapeuticsMD at 1-888-228-0150

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